There's been an interesting talk on this a few months ago:

- http://blog.cr.yp.to/20150314-optimizing.html

- (PDF) http://cr.yp.to/talks/2015.04.16/slides-djb-20150416-a4.pdf

Discussions:

- https://news.ycombinator.com/item?id=9202858

- https://news.ycombinator.com/item?id=9396950