1. Nowadays, options are priced in such a manner that the expected value of buying OTM hedges is almost always negative. This is due to the inflated volatility for out-of-money put options and other factors.
2. It just so happened that the subprime mortgage meltdown coincided with his career; for the period between 1935-2007, his strategy would not have worked. It also would not have worked between 2008-present. (maybe it worked have worked in 1987, so we're talking three instances out of a century). Right now, the evidence suggests bank have reformed their lending practices, with higher credit scores for new homeowners, so the odds of another financial meltdown are slim.
3. The fed balance sheet is big, but interest rates are very low.
The fed has posted a large profit , a 30% gain in 2015 for a profit over over $100 billion, which is sent back to the treasury
http://money.cnn.com/2015/03/20/investing/fed-profit-balance...
And the evidence due to the mathematics of the yield curve and the composition of the fed's holdings suggests the the odds of the fed losing money on it holdings is very low:
http://blogs.wsj.com/economics/2011/04/11/odds-of-fed-losing...
“Short-term interest rates would have to rise rapidly to quite high levels — in the neighborhood of 7% — for the Fed’s interest expenses to surpass its interest income. Such an outcome appears very unlikely,” the paper said. In the event that the Fed did face a loss, it could simply hand no money back to the Treasury and, “in the most extreme case, future remittances would also be reduced (and recorded as a change in deferred credit), but the Fed’s capital base and financial position still would remain completely secure.”
Japan has a much bigger debt, they seem to be doing fine. Low interest and srong dollar is due to reserve currency status, flight to safety, emerging market weakness, commodity weakness, petro dollar, the large size of the US economy, and other factors.