OP here. Yes, some of the stuff we deployed was packaged as .deb files - after vendoring all the dependencies.
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We usually stick to the official Debian python-* packages (if they exist upstream). When they don't we use python-virtualenv[1][2] to pull specific versions and dependencies from pip into a virtual env.
Now when we build our Debian package (debian/rules):
override_dh_virtualenv:
dh_virtualenv -p myproj --use-system-packages