I have tried several to-do list apps and nothing really does what I want it to. So far, the closest is TheDeadline but it is not a good fit for my work.

Probably a stupid thing to do (since I'll probably end up spending 25+ hours implementing it) but I am writing my own rails "anti to-do" app (my-foc.us). When I am happy with it, I'll turn on the new account feature. The book REWORK inspired me to just implement the features that I want, and to feel good about a minimalist app.