I am dissapointed: tried running it on a utility I wrote for crunching Wikipedia text (lots of string operations, some file IO) and it is so much slower than Ruby 1.9.1. I stopped the benchmark after 5 minutes (same test took about 70 seconds with Ruby 1.9.1). Then I tried a simple string manipulation benchmark, and it ran about 3 times slower in MacRuby.
Using Cocoa classes in MacRuby is great for Mac development but (apparently) really slows down string operations.