I highly doubt that there is a higher creature, whether that would be a God of some kind, or a whole civilization outside of our universe that somehow simulates us.
But let's for entertainment suppose that we are in fact a simulation. Would that not immediatly raise the question "why"? If we are a simulation I would really like to know the reason for being simulated. What do they hope to reach with simulating a life like ours?
I fear we could never find a satisfactory answer to these questions. I also agree with the statement that this brings us back to a more mythological explanation of the universe and life around us. It'd make more sense to try and explain our universe without that hypothesis to me.
Another argument that I'd like to raise against the universe-simulation hypothesis is the following. Humans like to see the world around them in terms of the technology that, at that moment, is considered modern and which they like. For example, Freud compared the human brain to the steam engine, which at that point was modern technology. Today, we compare the brain to a computer, and we even go as far as to consider the whole universe might be similated in one. Maybe just because that is what we consider 'modern' at the moment?
In 1000 years from now, humans might think it's silly to think of the brain as a computer and rather think of it in terms of technology X, and the universe is technology Y.