An open fuel cycle (without reprocessing) makes nuclear power pretty worthless, as has been shown in the US over the past 30 years.
President Carter banned reprocessing in the US over bogus weapons proliferation concerns; IMO, one of the worst things a President has done in the past 60 years.
I am a bit torn between "just build a lot of 3rd generation reactors" vs. going for the fourth gen designs.