Yes.
Multidisciplinary Association for Psychedelic Studies (MAPS, www.maps.org) is my #1 destination for donations. I think the war on some drugs has done more to damage the US than anything else, and this seems like the most reasonable pathway to fix this -- showing that various "evil" substances are medically useful.
I also donate to: EFF, Gun Owners of America, NRA, Tax Foundation, the National Cryptologic Museum, and the Singularity Institute for Artificial Intelligence.
I'd like to donate to global, national, and local (Seattle or WA/PNW) environmental groups which are responsible and not "Environmentalists"; buying land privately and being responsible with it seems to be a more direct way to accomplish this.