Uranium supply is limited, but there is far more Thorium.
Thorium technology is quite immature at the moment but India and China are developing it, although it'll take quite a while to get to third, or fourth generation level maturity.
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There's more Thorium in the crust, there's more Uranium in seawater. With either fuel (plus breeder reactors), the nuclear fuel supply of earth is unlimited on a several billion year timeframe at world-scale.
Well ther’s even more Hydrogen in sea water, the problem is getting it out.
Here's an entire special issue (from 2016) of Industrial & Engineering Chemistry Research describing progress in extracting uranium from seawater: http://pubs.acs.org/toc/iecred/55/15
Thorium though doesn't need isotopic enrichment though.
Neither does Uranium if you're using breeder reactors. And you have to be using breeder reactors if you're using Thorium because Th-232 is a strong neutron absorber and you can't start a reactor on it at all. You have to breed it up through Pa-233 to U-233 which is fissile. By definition all thorium reactors are breeder reactors. Fertile U-238 can do the exact same thing; instead of U-233 it breeds fissile Pu-239. If you want all the raw details on Thorium check this out [1].