"Given an 'experience machine' capable of providing whatever experiences we desire, in a way indistinguishable from 'real' ones, should we stubbornly prefer the truth of reality?"

If real and virtual are "indistinguishable", how can we be sure what is real and what is not? That's one of the themes I feel that was missed in The Matrix - there was never any doubt as to what was the real world and what was the virtual world. That I felt was much better explored in the contemporaneous eXistenZ, with its constant underlying doubts about "are we still in the game?"