https://www.arqbackup.com/ is great, you can choose your own backend store, like S3 or Backblaze B2.
And there's https://www.arqbackup.com/arqcloudbackup/ if you don't want to have to manage that yourself, a more direct competitor to Backblaze.
And there's https://www.arqbackup.com/arqcloudbackup/ if you don't want to have to manage that yourself, a more direct competitor to Backblaze.
I left because Google's rate limiting makes them really slow.
Also they mix together all errors including permission errors and "the file is being accessed by another program" so every run will have a few hundred errors (in fact, if I got zero errors that always a sign that the backup hadn't run correctly).
https://www.duplicati.com/ is a solid FOSS option as well though I've found it to be a much less polished experience than Arq.