One cool application that cropped up in the Rust ecosystem is to use WASM for procedural macros. That way not only can they be distributed as precompiled (arch-agnostic) blobs from crates.io, but you also get all the benefits of the sandbox environment to guarantee freedom from malicious side effects. The W in "WASM" doesn't have to limit possible applications to just the web browser.
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And once there is a GC, it will be a good target for script languages on the OS, as wasm compilers are optimized for fast starting.