Yeah, I have mine cranked all the way to the most amber. And when reading in bed at night, I'll also have the brightness at the absolute minimum.
Sometimes even that's not enough and I'll use the accessibility settings to make things even redder.
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YOu get the most eye-friendly setup by going further in Accessibility settings and enabling VoiceOver. Start off with a slow speech setting, and try reading a few pages of text with it. I guess the most useful gesture for this is two-fingers-swipe-down, which will introduce VoiceOver to read all page elements from the current select one onwards
iBooks also has (or at least had last time I tried) pretty good VoiceOver support, will turn the pages automatically if you read with the mentioned two-fingers-swipe-down gesture.
The speech synth might need a little getting used to, but rest assured, what you're getting is way better then what people used to use in the 90s and earlier. Speech synths sounded a lot more unnatural then these days. I am mentioning this because it is actually a built-in feature. No need to install third-party apps. Of course, strictly speaking, this is a screen reader developed for the blind, but that shouldn't stop anyone to benefit from it when it comes to giving your eyes a break.