I did not take Jonathan Blow's tweet to be saying it's a bad idea, or won't work, but rather that it's an indictment of the whole web stack that it's necessary.
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Watch any of his talks and you'll know for him it's definitely the latter. He's complained about bloat and the web stack in particular plenty of times.
Here's a really good talk by him that dives into it, titled dramatically "Preventing the Collapse of Civilization": https://www.youtube.com/watch?v=ZSRHeXYDLko
Also note he's currently developing a programming language called JAI that's trying (and seems like it might ultimately succeed) in being a faster and smoother alternative to C++ for developing games.