I spent lockdown coming up with a music podcast with a friend, it's amazing how much even a little delay can throw you off. I have a hybrid digital/analogue setup where an analogue mixer is fed either from a digital source by a DAC or an analogue source via my microphone or a turntable. The analogue audio then goes through some analogue processing equipment and is then fed into the ADC and recorded/streamed digitally. It's not the most efficient setup in the world, but I have a real thing for flashing lights and physical switches!
If you talk into the mic with your headphones plugged into the analogue side then switch to monitoring the software instead, you can really notice the latency even though it's practically not that much. I read about a technology that's supposed to prevent angry customers from giving poor call centre employees a tirade of abuse by echoing their voices back at them on a very slight delay which is apparently quite intolerable, and I could believe it!