My n=1 - A Dell system, "16GB max memory" (Dell) vs. "32GB max memory" (web sites of some leading 3rd-party memory manufacturers). The latter seem to be correct. Both Windows 10 and the hardware self-tests in the Dell's BIOS fully support the extra memory.
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I've got an old HP business tower that only officially supports 4GB of DDR2 and has 4 slots.
Works just fine on 800MHz using 4GB total.
Needed to use 667MHz DIMMS so it would handle 8GB.
Almost worked with 800 but was unstable.