Quote:
“National data show an exponential increase in both new infections and test positivity rates during the first three weeks of this wave, indicating a highly transmissible variant with rapid community spread of infection.”
[1] https://www.nytimes.com/2021/11/28/world/africa/south-africa...
https://jim.bmj.com/content/69/6/1253
It's a small sample, but it was done on data available in 2020, which was before vaccines were available.
Small sample size, but even similar result is somewhat surprising -- I would've thought the 2nd infection would be weaker.
It's not that much larger -- I guess reinfections are hard to find -- but surprisingly this found that ICU admission was higher for reinfections.
And as for knowledge, step into a hospital, and you'll see plenty of medications being used to treat actual cases of COVID. Doctors don't just put an oxygen mask on your face, and wait for you to die. You'll find a bit more knowledge there than you will in a deraged InfoWars rant, or a Joe Rogan podcast.
Unfortunately, that knowledge doesn't have 190 million monthly listeners. [1]
[1] If the most popular podcast[2] in America is your definition of 'eradicating' discussion, it's certainly an odd one.
[2] Or, if you're looking for variety in your media, you could always tune in to AM radio. Or the biggest television news syndicate in the world.
Everyone knows Paxlovid is safe and effective too, but you aren't allowed to take it yet.
"Do the Selective Serotonin Reuptake Inhibitor Antidepressants Fluoxetine and Fluvoxamine Reduce Mortality Among Patients With COVID-19?" – https://jamanetwork.com/journals/jamanetworkopen/fullarticle...
"Mortality Risk Among Patients With COVID-19 Prescribed Selective Serotonin Reuptake Inhibitor Antidepressants" – https://jamanetwork.com/journals/jamanetworkopen/fullarticle...
"Mortality risk is confirmed to be significantly decreased among patients with #COVID-19 prescribed SSRI antidepressants, and particularly #fluoxetine, and fluoxetine or #fluvoxamine, in a large (n>80,000) US observational study." – https://twitter.com/HoertelN/status/1460309793558646785?s=20
Dr. Farid Jalali's track record on accuracy of statements on the pathophysiology is excellent. Here's a thread that outlines how and why SSRIs work to reduce illness in COVID: https://twitter.com/farid__jalali/status/1440876997182300169
Platelets and serotonin are involved in the disease. Serotonin tends to cause inflammation, clotting, and vasoconstriction. A significant feature of COVID-19 is elevated plasma serotonin. (Here's an almost random source for this: https://twitter.com/ivanajpavlovic/status/146071264917663334... ... another: https://twitter.com/__ice9/status/1345194722055385091 ... these are tweets, yes, but they link to papers.) Platelets have serotonin transporters and serotonin receptors. SARS-CoV-2 does a lot of things; One of the things it does is that it kills platelets by inducing necroptosis (source: https://twitter.com/DrKoupenova/status/1418558896390688776?s... ). This releases the serotonin inside them, causing other platelets to clot. SSRIs block platelets from picking up serotonin produced and secreted by enterochromaffin cells in the digestive tract; This is the source of the platelets' serotonin payload (more here: https://en.wikipedia.org/wiki/Enterochromaffin_cell ). If an SSRI is taken early, platelets will have reduced serotonin payloads, which limits the serotonin-induced damage to the lung.
I had no idea about any of this until recently.
Another thing I had no idea about: Serotonin is metabolised by the lungs. https://twitter.com/ablative_sasha/status/144016208428566528... — and COVID-19 damages the lungs. It's a bad feedback loop involving way too much free serotonin.
There are other things at play but this is one of them. SSRIs work for a lot of patients, have a significant and confirmed benefit, and a mechanism of action that makes sense.
I've also seen pretty substantial claims / results that arginine, N-acetylcysteine, and melatonin seem to help. The best way to dig up those scientific results that do exist on it is actually to search Twitter for it. Try to find reliable-seeming scientists that are linking to actual papers and are careful in not suggesting too much.
[0]https://floridahealthcovid19.gov/monoclonal-antibody-therapy...