How similar is this to the protease inhibitor Ivermectin?
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Ivermectin is not a protease inhibitor. From wikipedia:
> Ivermectin and its related drugs act by interfering with the nerve and muscle functions of helminths and insects. The drug binds to glutamate-gated chloride channels common to invertebrate nerve and muscle cells.
Cited from:
There does seem to be some protease inhibition involved.
An in silico data analysis conducted by Choudhury et al. demonstrated that ivermectin efficiently utilizes viral spike protein, main protease, replicase, and human TMPRSS2 receptors as the most possible targets for executing its "antiviral efficiency" by disrupting binding.[1]
From the article I cited:
"Taken together, our data on the interaction between ivermectin and viral proteins indicated that ivermectin majorly acts by interfering with the viral entry through inhibiting the function of spike protein and protease. "
Protease binding is in fact a thing that Ivermctn does: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996102/
This drug works for treating COVID-19 and Ivermectin does not.
Ivermectin works to remove parasitic worms and kill malaria though and Paxlovid has no evidence indicating it does so.
Not at all. We had this article a while back which will hopefully nip this topic in the bud. https://astralcodexten.substack.com/p/ivermectin-much-more-t...
It's $700 USD per course of treatment vs. $10. Obviously very dissimilar.