At least with McDonalds, you know what goes into it. They actually have a nutrition label. Show me the nutrition label of the Italian bistro. If you asked, you'd probably get kicked out because you insulted the chef.
So, actually, I'll be way more confident about my health (that's what it's called, not safety, food safety is about you not getting poisoned) eating at McDonalds, than at some rando uptown joint.