Using plywood for all of the structural components means if you get a leak, which all houses get, you are in danger of much more significant damage than lumber framing. And with this system you still need to do all the normal things to build a house (get a designer, route plumbing, electrical, get a civil engineer, install all that stuff, etc.) just instead of framing you have custom blocks you need made.
I just don't think these make sense.