I think this is right. For counterpoint though, there will of course be variance, but an opposite hypothesis is a larger proportion have labor jobs (men moreso than women).

Grew up in rural PA (mostly farming, some factory work). They exact a significant toll (part of the reason opioid dependence grew IMO).

But most of the metrics I have been seeing in terms of death rates show it is both for men and women, so I don't think labor jobs can explain it.