It may be a stupid question, but is there already some DOM access or a dedicated package that allows writing web applications in this compiled python?
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Yes. Here is an example how to integrate Python to React front end
https://blog.pyodide.org/posts/react-in-python-with-pyodide/
Similar examples for raw DOM manipulation should be available for Pyodide as well. It has bindings to all JS code, so it can do everything that JS can do.
Thanks. I know about the one for Pyodide. Is it confirmed that it works for this new py2wasm compiler?