I am programming C because Python is too slow for my use case (and too annoying and to unstable) and yes, I use C's integer types as an abstraction for mathematical integers. And I would say this is the case in almost all C code I see and most programmers I talk to. How would two-complement's wrapping for int be useful for anything? It does not model anything useful IMHO.
And the problem with compilers not optimizing is that people want them to optimize... Compilers not being able to to do this as well anymore would indeed be an actual problem for many people.