Would you expand on that? Having done a small amount of learning adjacent to this work, I’d like to find out more.
I was introduced to Friston’s work through “The Hidden Spring” by Mark Solms [0]. It seems well grounded in theory that there exist certain materials that maintain a specific range of entropy (S). Within some of those materials (i.e. biological), there are meta materials that enhance entropy maintenance by forming communication/processing networks. These networks are bounded in certain ways, say within the behaviors exhibited by a single cell organism, to much more broadly between neurons of an animal that has them. People then get hung up on what is meant by Bayesian and “Markov blankets.” [1]
Stipulating thoughts arise from biological underpinnings rather than something supernatural doesn’t strike me as “mumbo jumbo.” Applying math based on a well defined (but may well be incorrect) physics theory to define the meta material from which thoughts arise seems to be a quantization that may lead to stronger links between biology and psychology. To the degree that consciousness is primarily a psychologically defined phenomena, this is work that could reduce much mumbo jumbo.
0. https://www.amazon.com/Hidden-Spring-Journey-Source-Consciou...
1. https://slatestarcodex.com/2018/03/04/god-help-us-lets-try-t...
https://plato.stanford.edu/entries/pseudo-science/#Fals
Popper even thought evolution by natural selection was not falsifiable.
If you keep reading, you that this led to Kuhn's criticism of Popper's approach, and his motion of scientific revolutions, which we see actually being practiced: particle dark matter has technically been falsified many times, but we didn't throw it out but instead revised it to accomodate new data. It is only when these sorts of revisions become less plausible compared to a totally different approach that science meaningfully progresses.
But for your second sentence, do you have in mind a hypothesis which you think is not testable but is still part of scientific inquiry?
Atomism was certainly not testable when it was first proposed by the ancient Greeks, and yet here we are. What is unscientific today could be scientific tomorrow (or in a thousand years). I would argue that figuring out how to (dis)prove something is also part of scientific inquiry.
But, in separating scientific from non-scientific claims, can we not distinguish those that are in some way motivated by some limited available evidence, and which would be testable with some kind of evidence which we can describe how to get in principle (if not practically), from those that don't have any real path towards being falsified?
I think roughly that Democritus probably got lucky and was essentially making a philosophical claim, and that we selectively choose to focus on the parts that were eventually found to line up with scientific results. Apparently he also believed that some atoms were hook-shaped and others eye-shaped, and though the specific texts are lost, it's hard to see how he could have arrived at that through "scientific" means.
https://en.wikipedia.org/wiki/Atomism#Democritus
If you wanted to say that something with no path to being testable is "science" because in the long arc of history we can't rule out that it might eventually be testable, then one has to admit a bunch of weird stuff into "science". No one today can guarantee that 2500 years in the future someone won't figure out the technology for inter-dimensional observation, and we'll find that in the next universe up we can listen to God talking to his choir of Angels -- but the absence of such a guarantee doesn't seem like sufficient grounds for someone to say "Abrahamic monotheism is a scientific hypothesis; we just don't have the apparatus to test it out yet."