I've always wanted to test if dropping acid affects my problem-solving abilities in any way but I still haven't done so. As soon as the effect begins, I stop being fascinated by computers at all. Living things and music are so much more interesting to watch and interact with.

Perhaps this doesn't hold true for abstract or deep problems. I remember feeling aversion to Django, jQuery and the ugly (as in 'practical') mix of technologies that the modern web stack is.

I think this has to do with a more sensitive perception of beauty and 'purity'. Perhaps thinking of solving more abstract problems using higher-order techniques in LISP, Clojure or Haskell would've been a more pleasurable and rewarding experience. I'm normally turned on by sexy UI and not so much by algorithms, but at least I learned firsthand you don't want to work on your webapp under acid, it's just not fun.

I also had a somewhat negative experience with using GUI. It was very painful to use YouTube because it is packed with things you don't want to see. Normally, your eye ignores anything but what you focus on, but LSD seems to remove this filter so you actually have to experience everything: ads, unpleasant people in related videos. Google Suggest is especially maddening because it gives you ten things you don't want, and you can't just ignore it.

I also recall it being very difficult to make money transactions (i.e. buy some tea at the shop). Money and numbers seem very arbitrary and it's hard to focus on them.