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by dcminter·1y ago·view on hn ↗
Epidural is surely just the method of administration (into the spinal fluid) where the actual painkiller administered is opioids, though, right?

Meanwhile my understanding of Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) was that they were exactly that by definition - Anti-Inflammatories with pain being reduced by reducing the immediate cause of it, inflammation, not by interfering with the actual mechanisms of pain.

I guess one could consider general anaesthesia (laughing gas, ether, and more modern successors) to be "painkillers" too but they're obviously not quite the same category of thing.

Anyway, I enjoyed the article - it would be interesting to hear the author give their own reasons for not accounting for NSAIDs.

1 comments
Paracetamol/acetaminophen is not an NSAID, though.

NSAID is effectively a shorthand for COX inhibitor; the term NSAID was coined at a time when the mechanism wasn't fully understood, and all other anti-inflammatories were steroids.

Paracetamol does target COX-2, but does so in a way that doesn't really have any effect on inflammation. Its main mechanism of action is as an AM404 inhibitor.