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by nikolay·10mo ago·view on hn ↗
There's always a risk with any intervention. The vast majority of people don't get ulcers from ibuprofen, aspirin, etc. To suggest taking it with omeprazole is crazy! DGL and vitamin C alongside aspirin almost fully eliminates the risk of stomach bleeding, so, I assume the same applies to ibuprofen.
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If one doesn't get an ulcer from ibuprofen, then obviously there is no reason to take it with omeprazole, etc. One can take it for decades and not get them, then suddenly something changes and one start getting them. That's when the co-protection starts to be needed. There is nothing crazy about it.

As for low-dose aspirin, its safety is dose, formulation, and frequency dependent. There is a reason why many doctors don't suggest its casual use anymore. Low-dose aspirin often also leads to bruising, sometimes very large black bruising, in random regions of the body.

Vitamin C alone won't eliminate the risk. As for the combo of DGL with vitamin C, I will have to try it.

The study is not about combining vitamin C with DGL, but that could be an even better option. Anyway, unlike antacids or PPIs which neutralize or block acid, DGL is considered a "cytoprotective" agent—meaning it directly protects the stomach cells.
In those vulnerable, protection is needed continuously for 24-48 hours when taking ibuprofen, even while sleeping.

I don't know how long DGL works for, or how often it has to be dosed. I suppose it could be useful more generally as a baseline supplement, just like vitamin C.