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by brandonb·9mo ago·view on hn ↗
Unfortunately, this is a limitation of nearly all nutritional studies.

Partly we use mechanistic evidence to separate cause from effect--that's part of why the article goes into detail about, e.g., how soluble fiber binds to bile in the liver. If there's an association between A and B, and a known physiological mechanism where A causes C which causes B, it makes it more likely that ultimately A is the cause of B.

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It's a limitation of all epidemiological studies. These are a great way to target more expensive randomized controlled trials that are also more invasive by definition. Nutrition science has lots of those and needs more.

In an N=1 intervention study, I too found fiber to be health supporting, but that wasn't randomized or controlled.