From Wegovy itself? Naturally so, while actively losing weight - before it reached equilibrium so for first 5-7 months - i did, everyone does. When losing weight as quickly as that, the body assumes that "i've got almost no food and am starving, perhaps gonna die soon", which naturally makes a person depressed. When someone is dieting the "good old way", they feel acutely hungry all the time so don't concentrate on emotional part and it's probably not nearly as bad for them, but on Wegovy, one doesn't get hungry.

But once weight stabilised, this goes away and then the mood is pretty stable.