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by brandonb·6mo ago·view on hn ↗
> My doctor said she’s seeing a huge number of patients coming back with excessively high Vitamin D levels after taking supplement doses recommended by influencers. It happened to me, too, with what I though was a conservative dose of Vitamin D (5K IU, not even taken every day)

IMO that’s part of what’s interesting about this study design — they tested vitamin D blood levels and adjusted the supplement dose based on that. This seems like a much better approach than taking a high dose blindly.

I think the headline is accurate. The 52% number is from the experiment arm (participants who received a vitamin D supplement, with the quantity guided by blood testing). While it’s technically possible for the supplement dosage to be calculated as zero, 85% of participants were deficient at baseline, so this isn’t the main effect.

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> I think the headline is accurate. The 52% number is from the experiment arm (participants who received a vitamin D supplement, with the quantity guided by blood testing). While it’s technically possible for the supplement dosage to be calculated as zero, 85% of participants were deficient at baseline, so this isn’t the main effect.

Yes, but it's also important to note that the study wasn't on a representative sample of the general population. They recruited people who had acute coronary syndrome. The average age was over 60 years old, 80% were men, and half of them had already had at least one heart attack.

I think the supplements are just average Vitamin D off the grocery store shelf. Malabsorbtion is obvious possible.