Take the way AI is being developed as an example. People rush to build giant agents in giant datacenters that are aligned to giant corporations and governments. They're building the agentic organism equivalent of machiavellian organizations, even though they'd be better off building digital humans that are aligned to individual humans that run on people's gaming PCs at home. They will find out that the former is the wrong architecture, but the cost of that failed iteration is the future of human civilization, and nobody gets a second try.
Of course, this is an extreme example on one end of the scale. On the other end, it wouldn't matter at all if you're building a small game for yourself as a weekend project with no users to please or societal impacts to consider.