... in mice.
More than 90% of "in mice" studies do not transfer to humans.
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I wonder how often a medicine that would have worked in humans doesn't transfer to mice, resulting in it being rejected.
all the time. lack of appropriate/translatable preclinical models is one of the largest barriers to new meds. in practice, if you can't find a mouse that has the same disease its almost impossible to prove your cure works,, even if it would in humans