With 64 GB of unified memory, you should be able to run a DeepSeek V4 Flash quantisation at 7–10 t/s, for example with: https://github.com/antirez/ds4 or https://github.com/steadfastgaze/MoEspresso (my engine).
The routed experts needed for the next tokens that are not already in memory need to be read from the SSD, so the speed becomes SSD reading bound and the larger the memory, the faster the inference.
Also, FWIW, I've been experimenting with Laguna-S-2.1. It runs reasonably quickly (llama.cpp, IQ2_M quant) but the outputs so far aren't impressive, and it gets stuck and perseverates. Very subjectively, at that level of quantisation, it seems to perform worse than Qwen 3.6 27B at Q4_K_XL.
Some parts are needed to generated every single token and these really should fit in memory, but the router experts that are not neeed can rest on SSD and be read only if they are needed, so... you can run MoE models bigger than you memory, try the IQ2XXS.
It should work on your 64 GB after you enable SSD mode in DwarfStar (in MoEspesso it enables itself), while being slower, so... I am really hoping for good models between the 50-120 GB other than Laguna, there is a big gap right now unfortunately.
Agree on the sizing - selfishly, something like a 60B MoE would be great - fast on big machines, and a 4 or 5 bit quant should fit in 64GB and still work well.
Maybe use it for overnight batch work! Hopefully, you aren’t suggesting it using for realtime conversations!