No, no it's not a mere misalignment. Opposing fascism supported on dehumanizing policies such as racial supremacy is not a mere difference in opinion, as is pushes to invade and annex other countries.
WW2 wasn't fought because people happened to disagree. The problem with Nazi Germany and imperial Japan was not a whimsical difference of opinion. Let's not pretend that the US is any different.
I'm not sure, I'd say two things:
- I think "mere difference of opinion" suggests disagreements can't be on serious issues, as if there's something trivial about "x things racism is acceptable a y doesn't". I don't know that I'd agree? Differences in opinion can be on major issues and are important. - Pushing to invade and annex countries is a real thing, which I said in my comment above, I don't know that interferences like Vance in Hungary are pushing to invade countries though? Other things the US doss might be, but I'm not sure it comes into play here?
Invading Greenland, annexing Canada, and helping Russia invade half a dozen neighboring nations while waging economic war on Europe in the form of tariffs is far from mere "differences of opinion".