It certainly seems unlikely, but I guess it depends on how fast asm.js can get.
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Now only 1.3x slower than native on one large-ish benchmark (box2d): http://youtu.be/qrf9ONmtXbM (I love the comparison he makes to evolution at the end. Yes, the process may give ugly creatures sometimes but they work.)
Unless you have a system with 4-8 cores and SIMD, and you want to leave a multiple of performance on the table: http://arstechnica.com/information-technology/2013/05/native...
For example, 1200% slower in Mandelbrot rendering with asm.js vs OpenMP C code.