CoffeeScript page: "CoffeeScript is a little language that compiles into JavaScript."
Brython page: "Brython is designed to replace Javascript as the scripting language for the Web."
Maybe that's the end goal, but the reality is far from it. Of course JS is still required, and of course the Python gets compiled into JS.
Finally, the approach seems a bit off. I would think it would be better for the Python to be compiled with a pre-processor, not done on the client.