It's "follow your bliss" not "follow the sparkles". It's not about avoiding sacrifice -- Americans especially believe that suffering can be avoided and we tend to live our lives on a junk food high -- but finding what makes you happy in the long-term and generally focusing on that. You will sacrifice and suffer a lot in your life, no matter what you do. Running away from it is not the solution. The bliss he's talking about, if you can find it, winds its way like a ribbon through the average day.