There is an immensely rich universe of languages you can chose from today. If you want Lisp-ish lambdas and macros, you should, by all means, go with Lisp. If you want to build your own DSL, you may as well chose Ruby. If you want pythonic indentation-as-structure, you should go with Python and, if you love the "do this if that" thing, you should consider Perl.
Having said that, I would love if Python threads had better support for multi-processors. It's not like changing syntax and turning Python into something it isn't, it's just properly implementing something that should be there from day 1.