I agree with your points and, having done a lot of Zope/Plone programming in the past, your #1 is by far my #1 too. More than once I have sworn if I knew enough of the inner workings of CPython, I would solve the problem myself, even if it took years of labor, even if I had to rewrite each and every module out there ;-)
I think my rather inadequately thought out response was because most of the comments here in HN were about changing Python into something else. I am truly sorry I implied your article was about turning Python into something unnatural and I most certainly owe you an apology.