Use Electrum as your Bitcoin client. Doesn't need to sync entire blockchains, it's super-fast and also can generate a wallet based on a passphrase so you can recover a wallet if your hard drive crashes.
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Ah, nice. Open source and lighter weight. This could be a good candidate for the PortableApps.com app store as you wouldn't need the 15.4GB and climbing full bitcoin blockchain on your portable device.