I haven't used a mouse on my desktop (any desktop, really) in over four years - I use Apple's Magic Trackpad to get the same experience and precision I have on my laptop.
That said, considering that many more people use laptops these days, mouse chording is somewhat passé and hasn't caught up with the times. But I'd actually rather have the window manager work more like other environments (without using different buttons to get different behavior on window edges) and would love an actual compositor and better font rendering.