raphlinus

Keyboard shortcuts should be doable, I don't think this is a limitation of the toolkit. Obviously screen readers are an important step, but we hope to be working with AccessKit. In any case, thou…

The original paper was discussed here a few days ago, with a fair amount of commentary before it was (rightfully) flagged[1]. A lot of the discussion was speculation, and this blog post (by the excell…

Some more background on this. First, an interview in Science from a few months back[1]. I very much trust the reporting in that interview (Kai Kakape is an award-winning science journalist), but it al…

Several problems with this response. First, the line quoted from the highlights section is referring to the 1054 antibody, which was isolated from a patient infected with SARS-CoV-2, as opposed to one…

Not only that, but a tweet from someone who has earned the title, "the pandemic's wrongest man". ETA: And to critique the substance and not the messenger, I have tried to track down any…

Here's a scientific paper which presents the case that your link is misleading: https://ebm.bmj.com/content/early/2021/05/26/bmjebm-2021-111... …

> So far the scientific literature has not established any conclusion on the risk of ADE with respect to COVID-19 vaccines. This may be understating the evidence. Derek Lowe cites this paper[1] wit…

More background, well written and accessible to a wider audience: https://blogs.sciencemag.org/pipeline/archives/2021/02/12/an... An interesting fact: concern…

Thanks for explaining your thinking. I like your theme and think it's worth discussing, but honestly this paper is only tangentially relevant. It would be relevant if ADE were a thing, but basica…

I flagged this. It's a perfectly fine paper, and quite interesting to someone with a deep interest in virology. However, the only purpose I can possibly see it serve in a Hacker News discussion i…

I like 7guis, and we use it as a way to think about what we're doing. However, I think the focus of 7guis tends to be much more on the higher levels of the GUI stack, particularly how to express …

That is basically the pitch for Metamath Zero[0]. I'm philosophically aligned with you. Basically, I think this is because of where resources are invested - there's a tremendous amount of …

Of the things I'm familiar with that are out there, this looks most familiar to Idris 2. Also, while Lean is primarily used for mathematical proofs, Lean 4 is beefing up its capabilities to be us…

The idea of being at or near herd immunity has been pushed so many times since the start of this pandemic, and each time those hopes have been dashed. The threshold needed for herd immunity has been r…

I think you added the links in an edit? The Science cite shows something that's very different than what people might take from your comment. Briefly, prior infection plus one mRNA dose induces a…

Thanks for bringing this paper, it's relevant to the conversation. A couple of points of context. First, this study is quite early on in the vaccination campaign, when supplies were very short. T…

For people curious about ADE (a fascinating topic that so far doesn't seem to have caused problems with SARS-CoV-2), here is some excellent background reading that covers many of the points made …

Antibodies wane, but B-cell and T-cell response is important for longer term protection. Fortunately, we have results (including [B] and [T]) that vaccines also induce these memory cell responses. A…

Thanks for trying to bring more precision to the discussion. I also cited that blog post elsethread, and, having reviewed it, agree it's not the single best piece of evidence. It establishes a na…

https://theconversation.com/covid-vaccines-focus-on-the-spik... is probably relevant to your question. The short answer (this was also discussed recently on TWiV) is that spike is the…

It is one datapoint among many, but I found it interesting because it is based on careful biological experimentation and directly compares immune response from vaccination and prior infection. Another…

I know this thread is catnip for the antivax contingent that reliably appears, but this argument has several problems. First, our vaccines provide a stronger immune response than infection, as has bee…

Here is the "Commodity Jurisdiction Request" for the RSA in Perl t-shirt, mentioned in TFA: http://cypherpunks.venona.com/archive/1995/10/msg00317.html My rec…

It is true. The claim was that the risk of addiction was extremely small. One of the ways this idea was pushed was cherry-picking a study that showed no addiction among 10k burn victims treated with o…

That is a dramatic misrepresentation of that preprint. The number of deaths is small enough that it is hard to draw inferences from it, and that was not the endpoint of the study. Rather, the key find…

You're correct that paper is about alpha, not delta. Apparently the CDC official pages haven't been updated with delta, but when they are (based on leaked internal presentations) it's l…

The pro-disinformation comments here on Hacker News are entirely predictable, yet make me despair for humanity. I'd love a site where bad faith arguments are unwelcome, but heterodox opinions a…

No. The movie claims that the virus was manipulated in a lab, specifically evolved from SARS-CoV-1 (which has only 79% genetic similarity). While this belief is very common in some circles, no reliabl…

This is an excellent question, and one I hope others answer. Here's my personal take. First, prune out really low quality sources of information, as they perpetuate uncritical thinking. The wor…